Caffeine is known to cause a comedown effect after a couple of hours, which leads to even more fatigue. This ultimately leads to drinking more coffee or taking higher doses, which causes tolerance in the long term.
Research in both animal and human has demonstrated that theacrine does not result in a fatigued crash or lead to tolerance build up over time. In a placebo-controlled study, theacrine demonstrated non-habituating effects in 60 healthy humans over 8 weeks of daily use at up to 300 mg/day.
Also unlike caffeine, theacrine doesn’t seem to affect blood pressure, cause anxiety, or lead to insomnia.
In addition, it may have benefits that caffeine doesn’t, such as decreasing inflammation and relieving pain.
However, these two compounds are more effective when taken together because caffeine increases the bioavailability and positive effects of theacrine.